Monday, January 19, 2015

4.  Analyze a HeLa cell karyotype.


As you can see, compared to the male karyotype, HeLa cells are far from normal. A normal karyotype has 46 chromosomes, 23 from the maternal side and 23 from the paternal side. However "[HeLa Cells] have the strangest karyotype" says Fischer. "They have 3 copies of this, and 2 copies of this, and 5 copies of that. They're not normal." HeLa cells have extra copies of some chromosomes and missing copies of others. They have 70-90 chromosomes with 4 copies of chromosome 12 and 3 copies of chromosome 6, 8, and 17 with 20 translocations. They are highly intricate which involve numerous chromosomal rearrangements. Because some scientists argue that the HeLa genome is not actually a human genome anymore, biologists consider cancer cells to be their own species. Not only did scientists find abnormalities in number but also in structure of chromosome and factors such as cancer cells losing healthy copies of genes. The chromosomes were arranged in the wrong order and didn't have the number of copies a normal chromosome does. 

Chromosomal disorders are usually caused by mutations that affect a chromosome. These defects are not passed down but is caused by a genetic error during mitosis or meiosis. During cell division, a body can accidentally create too many chromosomes or not enough. In both processes of cell division the expected number of chromosomes is supposed to end up in the daughter cells. Cells that don't have the normal chromosome number, can result in an error during division. Errors can also occur when a chromosome doesn't duplicate properly like in the S phase of Interphase. 

The other factor that causes chromosomal disorder is error in structure. This is when chromosomes are deleted, duplicated wrong, inverted, misplaced or exchanged with other chromosomes. Unfortunately, Henrietta Lacks had both structural and numerical problems with her chromosomes. 


 

7 comments:

  1. We used the same picture! I liked your explanation. Henrietta Lacks had an abnormal karyotype because of the HPV virus that attacked her cells. Another possible flaw in her cell cycle could have occurred during the anaphase stage. If the chromosomes pulled apart unevenly, this could have caused an uneven distribution of chromosomes and also led to cancer. Overall, you did a great job!

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